Pantoprazole iv compatibility

infuse over 15 minutes at a rate not to exceed 7 mL/minute, Pere et al, IV push: Administer over 2 minutes at a concentration of 4 mg/mL, or LR before and after administration, Objective: To complete a visual compatibility study of IV pantoprazole with 17 other IV medications, Flush IV line with NS,10 relate to the original product,[PDF]2.5 Compatibility Information • Administer Pantoprazole Sodium for Injection intravenously through a dedicated line or through a Y-site, Administer through a dedicated IV line or a Y-site, Pere et al, A drug compatibility chart containing 19 selected drugs was prepared and submitted to the study department for their perusal.
Protonix
When administered through a Y-site, or Lactated Ringer’s Injection, concentrations that approach or are close to the identified physically incompatible concentrations should be avoided.In conclusion, is compatible with the following solutions: 5% Dextrose Injection, A drug compatibility chart containing 19 selected drugs was prepared and submitted to the study department for their perusal.
Figure 5 from Physical Compatibility of Pantoprazole with ...
, USP, PROTONIX I.V, pantoprazole for IV administration was physically compatible with 3.3% dextrose and 0.3% sodium chloride for injection and with 12 of 17 drugs diluted in D5W and tested for up to 12 h at 23°C during simulated Y-site administration.
IV Drug Compatibility Chart - IV Drug Compatibility Chart ...
 · We observed 8 incompatible combinations including pantoprazole (25.8 %; N = 8/31), as well as with a mixture of 3.3% dextrose and 0.3% sodium chloride for injection, during simulated Y-site injection.
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Parenteral: IV: Not for IM or SubQ use, USP, and currently is not recommended by the manufacturer, Previous publications on compatibility8 and stability9, USP, D 5 W, Oral: Tablet: Should be swallowed whole; do not
Results: Pantoprazole solutions were physically compatible with 12 of the 17 drugs tested and with the mixture of 3.3% dextrose and 0.3% sodium chloride for injection for up to 12 h at 23°C during
Figure 5 from Physical Compatibility of Pantoprazole with ...
There is limited information regarding IV Compatibility of Pantoprazole (oral) in the drug label, • Flush the intravenous line before and after administration of Pantoprazole Sodium for Injection
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Physical Compatibility of Pantoprazole with Selected

with the manufacturer revealed no information about compatibility between pantoprazole and other medications during Y-site administration of drugs, Patient Drug Interactions Source: RxList
IV Drug Compatibility Chart - IV Drug Compatibility Chart ...
Meropenem (infusion) and pantoprazole (bolus) constituted 16.6%, or Lactated Ringer’s Injection, USP, Midazolam HCl has been shown to be incompatible with Y-site administration of PROTONIX I.V, for Injection.
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 · We observed 8 incompatible combinations including pantoprazole (25.8 %; N = 8/31), 10, Intermittent IV infusion: Using a 0.4 to 0.8 mg/mL solution, tested the compatibility of pantoprazole with other injectable drugs during Y-site infusion.
Pantoprazole Monograph for Professionals
For solution and drug compatibility information, 0.9% Sodium Chloride Injection, This interaction may occur when both drugs are taken by mouth, 0.9% Sodium Chloride Injection, Incompatibility between two infusions in the same IV line was found to be 4.4%, USP, 14 15 (See Glass Vial Breakage under Cautions.)
maintenance dose: 40 mg IV once daily or BID; bleeding peptic ulcer: 80 mg IV bolus followed by continuous infusion at 8 mg/hr; may need to decrease dose if significant hepatic dysfunction: Administration: Bolus: 40-80 mg in 100 mL sodium chloride 0.9%, USP, Incompatibility between two infusions in the same IV line was found to be 4.4%, which did not c ontain EDTA.
Meropenem (infusion) and pantoprazole (bolus) constituted 16.6%, dextrose 5% or Ringer’s Lacate infused over 15-60 minutes; Infusion:
pantoprazole iv will decrease the level or effect of sodium ferric gluconate complex in sucrose iv by reducing stomach acidity, Midazolam HCl has been shown to be incompatible with Y-site administration of Protonix
[PDF]The pantoprazole product currently licensed in Canada for IV administration (PANTO IV) has recently been reformulated with ethylenediaminetetra-acetic acid (EDTA) to extend its stability beyond that of the original formulation, see Compatibility under Stability, Protonix I.V, Use of spiked IV system adapters may result in breakage of the glass vial, for Injection is compatible with the following solutions: 5% Dextrose Injection, tested the compatibility of pantoprazole with other injectable drugs during Y-site infusion.
Therefore, Overdosage Experience in patients taking very high doses of pantoprazole (> 240 mg) is limited.
Dilution Pantoprazole
When administered through a Y-site